David Siegel

David Siegel is a computer scientist, entrepreneur, and philanthropist dedicated to advancing scientific discovery and shaping the public impact of technology. He co-founded the global investment firm Two Sigma and retired from day-to-day management in 2024, remaining chairman today. He is a Visiting Innovation Fellow at MIT, collaborating with students, researchers, and faculty to guide the Institute’s focus on leveraging artificial intelligence to support scientific discovery. Additionally, David is the founder of Open Athena, a nonprofit organization that bridges the resource gap between academic research labs and frontier AI. Through his foundation, Siegel Family Endowment, he supports leaders, researchers, and organizations that are examining how technological change affects society and how to guide that shift for the public good. David’s debut book, When Machines Act: The Promise and Peril of Navigating Our Agentic AI Future, co-authored with Yale’s Jeffrey Sonnenfeld and Stephen Henriques, will be published by MIT Press this March. Drawing on insights from over 300 CEOs and top technology leaders, the book provides a strategic framework for deploying, managing, and governing autonomous AI.